New research reveals that patients who come off blockbuster GLP-1 drugs like Mounjaro or Wegovy may regain reduced body mass much more quickly than those who halt conventional lifestyle regimens.
Research printed in a prominent medical journal demonstrates that while overweight people often shed about a fifth of their body weight while on the medication, the weight is regained at an average rate of 0.8 kg per month upon discontinuation.
"Users purchasing these medications should be informed of the danger of rapid weight regain when the therapy ends," cautioned lead investigator Dr. Susan Jebb.
Such speed of regain implies a reversion to original mass within about a year and a half.
Comparing Therapies
The study, which looked at dozens of studies involving thousands of patients, compared the outcomes of GLP-1 agonists with conventional dieting.
Scientists note that people who shed pounds through diet and exercise usually see a less rapid creep back—perhaps 100 grams monthly—once they finish.
Explaining the Quick Rebound
Experts suggest the mode of action of the jabs is key to understanding the amplified regain.
The injections copy a body's own chemical called glucagon-like peptide-1, which helps regulate appetite.
"Long-term administration of the hormone concentrations several times higher than the body's typical production may cause the body to produce less of its own natural hormone, and may also reduce sensitivity to its effects," said Dr. Adam Collins, a dietetics researcher.
"Withdrawal of this hormone supplement results in appetite is no longer kept in check, making binge eating much more probable."
A Chronic Disease?
Health authorities suggest the jabs for people with obesity-related health risks, accompanied by recommended lifestyle changes.
Professionals argue that, due to the likelihood of relapse, the treatment should be considered long-term.
This perspective is reinforced by drug manufacturers, who state that the findings "underscore the persistent nature of excess weight," similar to managing diseases like diabetes.
Patient Experiences
Individuals who have come off the jabs explain a powerful resurgence of cravings.
"It felt as if a trigger activating and you're instantly starving," said one woman.
The struggle is worsened if individuals have not developed lasting lifestyle or habit changes during treatment.
Growing Use
Recent estimates suggest that a significant number of people in the UK have used these injections in the past year, with demand continuing to grow.
- Use is higher among females than men.
- The middle-aged age group shows the highest level of interest.
- A large proportion obtain the drugs through private healthcare rather than the NHS.
In conclusion, experts caution that while these medications are effective tools for shedding pounds, they are not a standalone solution and maintained weight loss likely depends on combined behavioural management.
